Compound Sulfachlorpyridazine Sodium Powder
General name: compound sulfachlordazine sodium powder
English Name: Compound Sul fachlorpyridazine soil powder
Hanyu Pinyin: fufang Huang’ an Lidaqinna Fen
Sulfachlordazine sodium, trimethoprim
This product is light yellow powder
This product has a strong inhibitory effect on most Gram-positive and negative bacteria. Bacteria sensitive to sulfa drugs cannot use folic acid in the surrounding environment, but can only use p-aminobenzoic acid and dihydropteridine to synthesize tetrahydrofolate under the action of bacterial dihydrofolate synthase. Activated dihydrofolate plays an important role in the synthesis of purine and thymine nucleosides. Sulfa drugs are similar to p-aminobenzoic acid in structure. They can compete with p-aminobenzoic acid for dihydrofolate synthase in bacteria, hinder the synthesis of dihydrofolate, and finally affect the synthesis of nucleic acid and inhibit the growth and reproduction of bacteria. The effect of sulfonamides can be antagonized by drugs that can metabolize into p-aminobenzoic acid, such as procaine and Decaine. In addition, pus and tissue decomposition products can also provide essential substances for bacterial growth, which can antagonize sulfa drugs. Trimethoprim is an antibacterial synergist, which can inhibit the activity of dihydrofolate reductase. The combination of the two can produce synergistic effect and enhance the antibacterial effect.
(1) Some drugs containing p-aminobenzoyl, such as procaine and tetracaine, can produce p-aminobenzoic acid in the body. Yeast tablets contain p-aminobenzoic acid required for bacterial metabolism, which can reduce the effect of this drug, so it is not suitable for use
(2) When used with diuretics such as thiazides or furosemide, renal toxicity can be aggravated.
(3) Sulfa drugs can usually replace the following drugs with high protein binding rate, such as methotrexate, butazone, thiazide diuretics, salicylate, probenecid and letonin. Although the clinical significance of these interactions is not completely clear, the enhancement of the replaced drugs must be monitored.
(4) The combination of antacids and sulfonamides can reduce their bioavailability.
Sulfa antibiotics. It is used for the infection of Escherichia coli and Pasteurella in livestock and poultry.
Calculated by this product.
Oral administration: daily dosage, 32mg for pigs and chickens per 1kg body weight; Pigs, for 5 to 10 days: chickens, for 3 to 6 days.
The main manifestations are acute reactions such as allergic reactions, and chronic reactions include granulocytopenia, thrombocytopenia, liver damage, kidney damage and central nervous toxicity. It is easy to deposit in urine, especially when high-dose drugs are used for a long time.
(1) Chickens that lay eggs for human consumption shall not be used during the laying period.
(2) It should not be used as a feed additive for a long time.
(3) It is easy to precipitate crystals in the urinary tract, and the affected animals should be given plenty of water. The same amount of sodium bicarbonate should be given at the same time for large dose and long-term application.
(4) When the renal function is damaged, the excretion is slow, so it should be used with caution.
(5) It can cause intestinal flora imbalance, and long-term medication can reduce the synthesis and absorption of B vitamins and vitamin K. It is appropriate to supplement corresponding vitamins.
(6) It cannot be used in sick animals with a history of allergy to sulfa drugs.
Pigs for 4 days, chickens for 2 days.
1000g: sodium sulfachlordazine 625g+ trimethoprim 125g
It should be protected from light and sealed.
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